- Sept. 12 – MARSHALL (PC, BD) (cancelled)
- Sept. 12 – at South Carolina (cancelled)
- Sept. 19 – NORFOLK STATE (FW, HOF) (cancelled)
- Sept. 26 – UCF (TV: ABC) / L 28-51 (Attend: 350*)
- Oct. 3 – at Georgia State (TV: ESPNU) / L 29-49 (Attend: 3,823*)
- Oct. 10 – at USF (TV: ESPN+) / W 44-24 (Attend: 6,799*)
- Oct. 17 – NAVY (HC) (TV: ESPN2) / L 23-27 (Attend: 3,500*)
- Oct. 24 – bye
- Oct. 30 – at Tulsa (Friday) (TV: ESPN2) / L 30-34 (Attend: 0*)
- Nov. 7 – TULANE (MIL) (TV: ESPN+) / L 21-38 (Attend: 3,500*)
- Nov. 13 – at Cincinnati (Friday) (TV: ESPN2) / L 17-55 (Attend: 0*)
- Nov. 21 – at Temple (TV: ESPN+) / W 28-3 (Attend: 100*)
- Nov. 28 – SMU (SD, FA) (TV: ESPN+) / W 52-38 (Attend: 3,500*)
Final Record: 3-6, 3-5 AAC - Dec. 5 – AAC Championship Game (highest seed campus site)
Home games in ALL CAPS.
— * Attendance restricted due to COVID-19 policies
— American Athletic Conference games in purple.
— PC-Pirate Club Weekend, BD -Band Day, FW-Family Weekend, HC-Homecoming, HOF-Hall of Fame/Letterwinners Day, MIL-Military Appreciation Day, SD-Senior Day, FA – Fan Appreciation Day
— Game dates and TV scheduling subject to change