- Apr. 13 – GOLD (Offense) 71, PURPLE (Defense) 36
- Aug. 31 – at N.C. State / 12 pm / ACCN / L 6-34 (Attend. 57,633)
- Sept. 7 – GARDNER-WEBB (PC/FS) / ESPN3 / W 48-9 (Attend. 34,118)
- Sept. 14 – at Navy / CBSSN / L 10-42 (Attend. 30,707)
- Sept. 21 – WILLIAM & MARY (FW) / ESPN3 / W 19-7 (Attend. 38,094)
- Sept. 28 – at Old Dominion / ESPN+ / W 24-21 (Attend. 18,643)
- Oct. 3 – TEMPLE / 8 pm / ESPN / L 17-27 (Attend. 33,253)
- Oct. 12 – bye
- Oct. 19 – at Central Florida / CBSSN / L 28-41 (Attend. 42,906)
- Oct. 26 – South Florida (HC) / ESPNU / L 20-45 (Attend. 33,088)
- Nov. 2 – CINCINNATI (HOF/MIL) / CBSSN / L 43-46 (Attend. 32,273)
- Nov. 9 – at Southern Methodist / ESPNU / L 51-59 (Attend. 29,528)
- Nov. 16 – bye
- Nov. 23 – at Connecticut / ESPN3 / W 31-24 (12,084)
- Nov. 30 – TULSA (SD) / 12 pm / ESPNU / L 24-49 (Att. 27,978)
- Dec. 7 – AAC Championship Game (highest-seed campus site) / Time TBA / TV TBA
Home games in ALL CAPS.
American Athletic Conference games in purple.
American Athletic Conference games in purple.
PC-Pirate Club Weekend, FS-Faculty/Staff Appreciation Day, FW-Family Weekend, HC-Homecoming, HOF-Hall of Fame/Letterwinners Day, MIL-Military Appreciation Day, SD-Senior Day
Dates are subject to change pending finalization of television scheduling