- Sept. 1 – N.C. A&T (PC) [Postponed until Sept. 2 due to thunderstorms]
- Sept. 2 (Sun.) – N.C. A&T (PC) / TV: ESPN3 / L 23-28 (Attend. 38,640)
- Sept. 8 – North Carolina / TV: ESPNU / W 41-19 (Attend. 39,298)
- Sept. 15 – at Virginia Tech / [Cancelled due to Hurricane Florence]
- Sept. 22 – *at USF / TV: ESPNN / L 13-20 (Attend. 34,562)
- Sept. 29 – Old Dominion (FW) / TV: ESPN3 / W 37-35 (Attend. 35,047)
- Oct. 6 – *at Temple / TV: ESPNN / L 6-49 (Attend. 26,681)
- Oct. 13 – *Houston (HOF/FS) / TV: CBSSN / L 20-42 (Attend. 29,851)
- Oct. 20 – *UCF (HC) / TV: ESPN2 / L 10-37 (Attend. 31,159)
- Oct. 27 – Open Week
- Nov. 3 – *Memphis (MIL) / TV: ESPNU / L 41-59 (Attend. 29,127)
- Nov. 10 – *at Tulane / TV: ESPNN / L 18-24 (Attend. 20,860)
- Nov. 17 – *Connecticut (SD) / TV: CBSSN / W 55-21 (Attend. 27,234)
- Nov. 23 (Fri.) – *at Cincinnati / TV: CBSSN / L 6-56 (21,230)
- Dec. 1 – at N.C. State / TV: ACC Network Extra / L 3-58 (57,223)
Home games in bold.
American Athletic Conference games in purple.
American Athletic Conference games in purple.